Research Mission

Our primary research interest is defining and understanding the genetic architecture of human traits. To achieve our goal, we use a combination of approaches adopted from the fields of genetics, computer science, and epidemiology. We use multiple study designs (case-control, cohort, family) and develop locally, or collaborate nationally and internationally, very large datasets for analysis. We apply (and sometimes develop) the necessary statistical, computational, and molecular tools to illuminate the underlying genetic architectures. Our ultimate goal is to apply our findings in the clinical setting and improve clinical diagnosis, treatment, and prevention of disease.

Research Focus

  • Age-Related Macular Degeneration (AMD)

  • Alzheimer’s Disease (AD)

  • Amish Population studies

  • Glaucoma

  • Autism Spectrum Disorders (ASD)

  • Computational Methods