{"id":579,"date":"2022-06-28T15:59:20","date_gmt":"2022-06-28T15:59:20","guid":{"rendered":"http:\/\/eaglep.case.edu\/haineslab_web\/?page_id=579"},"modified":"2022-09-30T17:02:12","modified_gmt":"2022-09-30T17:02:12","slug":"home-haines-lab","status":"publish","type":"page","link":"http:\/\/eaglep.case.edu\/haineslab_web\/","title":{"rendered":"Home Haines Lab"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.16.0&#8243; background_color=&#8221;#4c86ce&#8221; width=&#8221;100%&#8221; min_height=&#8221;646px&#8221; min_height_tablet=&#8221;943px&#8221; min_height_phone=&#8221;943px&#8221; min_height_last_edited=&#8221;on|phone&#8221; height=&#8221;535px&#8221; height_tablet=&#8221;928px&#8221; height_phone=&#8221;691px&#8221; height_last_edited=&#8221;on|phone&#8221; max_height=&#8221;1000px&#8221; custom_margin=&#8221;||-68px||false|false&#8221; custom_padding=&#8221;12vw|0|25px||false|false&#8221; top_divider_style=&#8221;wave&#8221; top_divider_color=&#8221;rgba(26,58,155,0.95)&#8221; top_divider_height=&#8221;13vw&#8221; top_divider_repeat=&#8221;1x&#8221; top_divider_arrangement=&#8221;below_content&#8221; top_divider_height_tablet=&#8221;13vw&#8221; top_divider_height_phone=&#8221;18vw&#8221; top_divider_height_last_edited=&#8221;on|phone&#8221; box_shadow_style=&#8221;preset7&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;-80px&#8221; box_shadow_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16.0&#8243; min_height_tablet=&#8221;&#8221; min_height_phone=&#8221;&#8221; min_height_last_edited=&#8221;on|phone&#8221; height=&#8221;847px&#8221; max_height=&#8221;873px&#8221; custom_margin=&#8221;-93px||||false|false&#8221; custom_margin_tablet=&#8221;14px||||false|false&#8221; custom_margin_phone=&#8221;17px||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16.0&#8243; text_font=&#8221;Archivo||||||||&#8221; text_font_size=&#8221;18px&#8221; text_line_height=&#8221;2em&#8221; ul_font=&#8221;||||||||&#8221; ol_font=&#8221;||||||||&#8221; header_font=&#8221;Archivo||||||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_font_size=&#8221;31px&#8221; header_2_font=&#8221;Arial|700|||||||&#8221; header_2_font_size=&#8221;40px&#8221; header_2_line_height=&#8221;1.6em&#8221; header_3_font=&#8221;Archivo||||||||&#8221; header_3_text_color=&#8221;#FFFFFF&#8221; header_4_font=&#8221;||||||||&#8221; header_5_font=&#8221;||||||||&#8221; header_6_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;40px|||-81px|false|false&#8221; custom_margin_tablet=&#8221;0px|||&#8221; custom_margin_phone=&#8221;|||-8px|false|false&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; header_2_font_size_tablet=&#8221;&#8221; header_2_font_size_phone=&#8221;28px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; header_3_font_size_tablet=&#8221;&#8221; header_3_font_size_phone=&#8221;&#8221; header_3_font_size_last_edited=&#8221;on|desktop&#8221; module_alignment_tablet=&#8221;center&#8221; module_alignment_phone=&#8221;center&#8221; module_alignment_last_edited=&#8221;on|tablet&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: center;\"><strong>The Haines Lab<\/strong><\/h2>\n<h3 style=\"text-align: center;\"><strong>Illuminating the genetic<\/strong><\/h3>\n<h3 style=\"text-align: center;\"><strong> architecture of human traits<\/strong><\/h3>\n<h3 style=\"text-align: center;\"><strong>__<\/strong><\/h3>\n<h3><strong><\/strong><\/h3>\n<h3 style=\"text-align: center;\"><strong>Alzheimer&#8217;s Disease<\/strong><\/h3>\n<h3 style=\"text-align: center;\"><strong>___<\/strong><\/h3>\n<h3 style=\"text-align: center;\"><strong>Age-related Macular Degeneration<\/strong><br \/><strong><\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/06\/m_i1552-5783-60-12-4041-f04-AW-bigger-version.png&#8221; title_text=&#8221;m_i1552-5783-60-12-4041-f04 AW bigger version&#8221; align=&#8221;center&#8221; force_fullwidth=&#8221;on&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;center&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-8px||||false|false&#8221; border_width_all=&#8221;6px&#8221; border_color_all=&#8221;#0439A3&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; prev_background_color=&#8221;#4c86ce&#8221; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.16.0&#8243; background_color=&#8221;rgba(26,58,155,0.95)&#8221; min_height=&#8221;641px&#8221; min_height_tablet=&#8221;812px&#8221; min_height_phone=&#8221;641px&#8221; min_height_last_edited=&#8221;on|phone&#8221; height=&#8221;656px&#8221; custom_margin=&#8221;-24px||-79px||false|false&#8221; custom_margin_tablet=&#8221;7px||-78px||false|false&#8221; custom_margin_phone=&#8221;||-80px||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;18vw|0|0px||false|false&#8221; top_divider_style=&#8221;wave&#8221; top_divider_height=&#8221;10vw&#8221; top_divider_height_tablet=&#8221;12vw&#8221; top_divider_height_phone=&#8221;15vw&#8221; top_divider_height_last_edited=&#8221;on|phone&#8221; box_shadow_style=&#8221;preset7&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;-80px&#8221; box_shadow_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16.0&#8243; custom_margin=&#8221;-167px||||false|false&#8221; custom_margin_tablet=&#8221;-114px||||false|false&#8221; custom_margin_phone=&#8221;-49px||||false|false&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text content_tablet=&#8221;<\/p>\n<h2>Research<\/h2>\n<p>Our work focuses on the genetic architecture of neurodegenerative and ocular diseases, with an emphasis on diversity, recognizing that these conditions manifest differently and at different rates in communities that historically have not been included in large-scale genetic research.<\/p>\n<p>Some of our foundational research has been among the Amish in Ohio, whose engagement has been instrumental in making breakthrough findings that inform their care and that can also be applied to larger and more diverse data sets.<\/p>\n<p>&#8221; content_phone=&#8221;<\/p>\n<h2>Research<\/h2>\n<p>Our work focuses on the genetic architecture of neurodegenerative and ocular diseases, with an emphasis on diversity, recognizing that these conditions manifest differently and at different rates in communities that historically have not been included in large-scale genetic research.<\/p>\n<p>Some of our foundational research has been among the Amish in Ohio, whose engagement has been instrumental in making breakthrough findings that inform their care and that can also be applied to larger and more diverse data sets.<\/p>\n<p>&#8221; content_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16.0&#8243; text_font=&#8221;Arial||||||||&#8221; text_font_size=&#8221;18px&#8221; ul_font=&#8221;||||||||&#8221; ol_font=&#8221;||||||||&#8221; header_font=&#8221;Archivo||||||||&#8221; header_2_font=&#8221;Arial|700|||||||&#8221; header_2_font_size=&#8221;36px&#8221; header_2_line_height=&#8221;1.6em&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_5_font=&#8221;||||||||&#8221; header_6_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;-37px||||false|false&#8221; custom_margin_tablet=&#8221;0px|||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; text_font_tablet=&#8221;Arial||||||||&#8221; text_font_phone=&#8221;Arial||||||||&#8221; text_font_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;15px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;&#8221; header_2_font_size_phone=&#8221;20px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Research<\/h2>\n<p>Our work focuses on the genetic architecture of neurodegenerative and ocular diseases, with an emphasis on diversity, recognizing that these conditions manifest differently and at different rates in communities that historically have not been included in large-scale genetic research.<\/p>\n<p>Some of our foundational research has been among the Amish in Ohio, whose engagement has been instrumental in making breakthrough findings that inform their care and that can also be applied to larger and more diverse data sets.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/04\/acp_pedigree_02052021.png&#8221; title_text=&#8221;acp_pedigree_02052021&#8243; _builder_version=&#8221;4.16.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-27px||||false|false&#8221; custom_padding=&#8221;||13px||false|false&#8221; border_width_all=&#8221;6px&#8221; border_color_all=&#8221;#4C86CE&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; prev_background_color=&#8221;rgba(26,58,155,0.95)&#8221; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.16.0&#8243; background_color=&#8221;#4c86ce&#8221; min_height=&#8221;510px&#8221; min_height_tablet=&#8221;580px&#8221; min_height_phone=&#8221;575px&#8221; min_height_last_edited=&#8221;on|phone&#8221; height=&#8221;384px&#8221; height_tablet=&#8221;580px&#8221; height_phone=&#8221;570px&#8221; height_last_edited=&#8221;on|desktop&#8221; custom_margin=&#8221;8px||-71px||false|false&#8221; custom_margin_tablet=&#8221;||-67px||false|false&#8221; custom_margin_phone=&#8221;8px||-70px||false|false&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;5vw|0|0px||false|false&#8221; top_divider_style=&#8221;wave&#8221; top_divider_height=&#8221;10vw&#8221; top_divider_height_tablet=&#8221;12vw&#8221; top_divider_height_phone=&#8221;15vw&#8221; top_divider_height_last_edited=&#8221;on|phone&#8221; border_color_all=&#8221;RGBA(255,255,255,0)&#8221; box_shadow_style=&#8221;preset7&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;-80px&#8221; box_shadow_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16.0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16.0&#8243; text_font=&#8221;Arial||||||||&#8221; text_font_size=&#8221;18px&#8221; ul_font=&#8221;||||||||&#8221; ol_font=&#8221;||||||||&#8221; header_font=&#8221;Archivo||||||||&#8221; header_font_size=&#8221;29px&#8221; header_2_font=&#8221;Archivo|700|||||||&#8221; header_2_font_size=&#8221;38px&#8221; header_2_line_height=&#8221;1.7em&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_5_font=&#8221;||||||||&#8221; header_6_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;41px||||false|false&#8221; custom_margin_tablet=&#8221;0px|||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;15px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;32px&#8221; header_2_font_size_phone=&#8221;20px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Publications<\/h2>\n<p><span>Our listed publications include those done in collaboration with various consortia, as well as those led by lab team members.\u00a0<\/span><\/p>\n<p><span>Many of our publications document landmark breakthroughs in genetics research, both for their specific findings and for their novel methodologies.\u00a0<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; 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prev_background_color=&#8221;#4c86ce&#8221; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.16.0&#8243; background_color=&#8221;rgba(26,58,155,0.95)&#8221; min_height=&#8221;600px&#8221; min_height_tablet=&#8221;737px&#8221; min_height_phone=&#8221;621px&#8221; min_height_last_edited=&#8221;on|desktop&#8221; height=&#8221;708px&#8221; max_height=&#8221;1000px&#8221; custom_margin=&#8221;||-78px||false|false&#8221; custom_margin_tablet=&#8221;||-87px||false|false&#8221; custom_margin_phone=&#8221;||-75px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;15vw|0|0px||false|false&#8221; top_divider_style=&#8221;wave&#8221; top_divider_height=&#8221;9vw&#8221; top_divider_height_tablet=&#8221;11vw&#8221; top_divider_height_phone=&#8221;15vw&#8221; top_divider_height_last_edited=&#8221;on|phone&#8221; box_shadow_style=&#8221;preset7&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;-80px&#8221; box_shadow_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16.0&#8243; custom_margin=&#8221;-117px||2px||false|false&#8221; custom_margin_tablet=&#8221;-79px||||false|false&#8221; custom_margin_phone=&#8221;-25px||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16.0&#8243; text_font=&#8221;Arial||||||||&#8221; text_font_size=&#8221;18px&#8221; ul_font=&#8221;||||||||&#8221; ol_font=&#8221;||||||||&#8221; header_font=&#8221;Archivo||||||||&#8221; header_2_font=&#8221;Archivo|700|||||||&#8221; header_2_font_size=&#8221;36px&#8221; header_2_line_height=&#8221;1.6em&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_5_font=&#8221;||||||||&#8221; header_6_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;-62px||1px||false|false&#8221; custom_margin_tablet=&#8221;0px|||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;||0px||false|false&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;15px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;&#8221; header_2_font_size_phone=&#8221;20px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Meet the Team<\/h2>\n<p><span>Led by Jonathan L. Haines, PhD, we are post doctoral fellows, PhD candidates, and staff whose research focuses on the genetic architecture of diseases that impact millions of people worldwide. <\/span><\/p>\n<p><span><\/span><\/p>\n<p><span>Our work is foundational in the quest for earlier diagnosis and prevention, as well as individualized interventions and therapeutics to deliver on the promise of precision medicine.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/07\/Haines-lab-2018-group-photo-2-color-cropped-sized.jpg&#8221; title_text=&#8221;Haines lab 2018 group photo (2) color cropped sized&#8221; _builder_version=&#8221;4.16.0&#8243; _module_preset=&#8221;default&#8221; module_alignment=&#8221;center&#8221; module_alignment_tablet=&#8221;center&#8221; 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