{"id":675,"date":"2022-07-05T19:01:44","date_gmt":"2022-07-05T19:01:44","guid":{"rendered":"http:\/\/eaglep.case.edu\/haineslab_web\/?page_id=675"},"modified":"2022-09-30T17:03:16","modified_gmt":"2022-09-30T17:03:16","slug":"our-research-2","status":"publish","type":"page","link":"http:\/\/eaglep.case.edu\/haineslab_web\/?page_id=675","title":{"rendered":"Our Research"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.16.0&#8243; background_color=&#8221;#54a885&#8243; width=&#8221;100%&#8221; min_height=&#8221;723px&#8221; height=&#8221;693px&#8221; max_height=&#8221;1000px&#8221; custom_margin=&#8221;||-68px||false|false&#8221; custom_padding=&#8221;12vw|0|25px||false|false&#8221; filter_contrast=&#8221;85%&#8221; top_divider_style=&#8221;wave&#8221; top_divider_color=&#8221;rgba(26,58,155,0.95)&#8221; top_divider_height=&#8221;10vw&#8221; top_divider_repeat=&#8221;1x&#8221; top_divider_height_tablet=&#8221;12vw&#8221; 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header_3_font_size_tablet=&#8221;29px&#8221; header_3_font_size_phone=&#8221;24px&#8221; header_3_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: center;\"><strong>Our Research<\/strong><\/h2>\n<h3 style=\"text-align: center;\"><strong>__<\/strong><\/h3>\n<p><strong><\/strong><\/p>\n<h3 style=\"text-align: center;\"><strong>Alzheimer&#8217;s Disease<\/strong><\/h3>\n<p style=\"text-align: center;\"><strong>___<\/strong><\/p>\n<h3 style=\"text-align: center;\"><strong>Age-related Macular Degeneration<\/strong><br \/><strong><\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/06\/Andrea-W-pathway-graphic-way-cool.png&#8221; title_text=&#8221;Andrea W pathway graphic way cool&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;center&#8221; align_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.16.0&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;390px&#8221; min_height_tablet=&#8221;260px&#8221; min_height_phone=&#8221;230px&#8221; min_height_last_edited=&#8221;on|phone&#8221; height=&#8221;260px&#8221; custom_margin=&#8221;-8px||||false|false&#8221; custom_padding=&#8221;|||25px|false|false&#8221; custom_padding_tablet=&#8221;|||1px|false|false&#8221; custom_padding_phone=&#8221;|||1px|false|false&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221; hover_enabled=&#8221;0&#8243; module_alignment_tablet=&#8221;center&#8221; module_alignment_phone=&#8221;center&#8221; module_alignment_last_edited=&#8221;on|phone&#8221; border_width_all=&#8221;6px&#8221; border_color_all=&#8221;#0439A3&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; prev_background_color=&#8221;#54a885&#8243; admin_label=&#8221;Subscribe&#8221; _builder_version=&#8221;4.16.0&#8243; background_color=&#8221;rgba(26,58,155,0.95)&#8221; min_height=&#8221;837px&#8221; min_height_tablet=&#8221;865px&#8221; min_height_phone=&#8221;980px&#8221; min_height_last_edited=&#8221;on|phone&#8221; height=&#8221;827px&#8221; height_tablet=&#8221;865px&#8221; height_phone=&#8221;980px&#8221; height_last_edited=&#8221;on|tablet&#8221; custom_margin=&#8221;-23px||-70px||false|false&#8221; custom_padding=&#8221;16vw|0|0px||false|false&#8221; filter_contrast=&#8221;85%&#8221; top_divider_style=&#8221;wave&#8221; top_divider_height=&#8221;10vw&#8221; top_divider_height_tablet=&#8221;10vw&#8221; top_divider_height_phone=&#8221;13vw&#8221; top_divider_height_last_edited=&#8221;on|phone&#8221; filter_contrast_tablet=&#8221;85%&#8221; filter_contrast_phone=&#8221;85%&#8221; filter_contrast_last_edited=&#8221;on|phone&#8221; box_shadow_style=&#8221;preset7&#8243; box_shadow_horizontal=&#8221;0px&#8221; 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ul_font=&#8221;||||||||&#8221; ol_font=&#8221;||||||||&#8221; header_font=&#8221;Archivo||||||||&#8221; header_2_font=&#8221;Archivo|700|||||||&#8221; header_2_font_size=&#8221;36px&#8221; header_2_line_height=&#8221;1.6em&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_5_font=&#8221;||||||||&#8221; header_6_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;-37px||||false|false&#8221; custom_margin_tablet=&#8221;0px|||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; custom_padding=&#8221;||0px|||&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;15px&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221; header_2_font_size_tablet=&#8221;&#8221; header_2_font_size_phone=&#8221;26px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Alzheimer&#8217;s Disease (AD)<\/h2>\n<p>The Haines Lab focuses on the genetic architecture of Alzheimer&#8217;s Disease (AD),\u00a0 drawing on vast data sets as well as unique and\/or historically underserved communities.<\/p>\n<p>Research within Amish communities has provided foundational insights more readily attainable because of the nature of these populations.\u00a0 {embed link}<\/p>\n<p>The Lab&#8217;s engagement with communities historically underrepresented in genetics research is based on a long-standing commitment to ensuring that all benefit from the foundational work that informs precision medicine for diagnosis, prevention, and treatment.<\/p>\n<p>The scale of data required for comprehensive genetics research requires collaboration through large consortia, many of them co-founded and directed by Dr. Haines.\u00a0 \u00a0{consortia page might be phase II)<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; 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custom_margin_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16.0&#8243; text_font=&#8221;Arial||||||||&#8221; text_font_size=&#8221;18px&#8221; ul_font=&#8221;||||||||&#8221; ol_font=&#8221;||||||||&#8221; header_font=&#8221;Archivo||||||||&#8221; header_2_font=&#8221;Archivo|700|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_5_font=&#8221;||||||||&#8221; header_6_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; custom_margin=&#8221;-20px||-3px||false|false&#8221; custom_margin_tablet=&#8221;0px|||&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; text_font_size_tablet=&#8221;18px&#8221; text_font_size_phone=&#8221;15px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;&#8221; header_2_font_size_phone=&#8221;26px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Age-related<\/h2>\n<h2>Macular Degeneration (AMD)<\/h2>\n<p>This is the most common cause of severe vision loss among the elderly.<\/p>\n<p>AMD is known for variable progression of the disease, although there are no well-defined biomarkers that track this progression.<\/p>\n<p>Since genetic variation strongly influences the risk of developing AMD, the Haines Lab hypothesizes that genetic variation also influences disease progression.<\/p>\n<p>This focus on progression complements the Lab&#8217;s ongoing work on the genetic architecture of risk and protection.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; 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