[et_pb_section fb_built=”1″ admin_label=”Subscribe” _builder_version=”4.16.0″ background_color=”#54a885″ background_enable_image=”off” width=”100%” min_height=”696px” min_height_tablet=”610px” min_height_phone=”485px” min_height_last_edited=”on|desktop” height=”696px” height_tablet=”610px” height_phone=”485px” height_last_edited=”on|desktop” max_height=”1000px” custom_margin=”||-68px||false|false” custom_padding=”12vw|0|25px||false|false” filter_contrast=”85%” top_divider_style=”wave” top_divider_color=”#0439A3″ top_divider_height=”10vw” top_divider_repeat=”1x” top_divider_height_tablet=”12vw” top_divider_height_phone=”15vw” top_divider_height_last_edited=”on|phone” box_shadow_style=”preset7″ box_shadow_horizontal=”0px” box_shadow_vertical=”-80px” box_shadow_color=”#ffffff” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16.0″ custom_margin=”-72px||||false|false” custom_margin_tablet=”-20px||||false|false” custom_margin_phone=”-20px||||false|false” custom_margin_last_edited=”on|desktop” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.0″ text_font=”Archivo||||||||” text_font_size=”18px” text_line_height=”1.2em” ul_font=”||||||||” ol_font=”||||||||” header_font=”Archivo||||||||” header_text_color=”#FFFFFF” header_font_size=”31px” header_2_font=”Archivo|700|||||||” header_2_font_size=”38px” header_2_line_height=”1.6em” header_3_font=”Archivo||||||||” header_3_text_color=”#FFFFFF” header_4_font=”||||||||” header_5_font=”||||||||” header_6_font=”||||||||” background_layout=”dark” custom_margin=”40px|||-81px|false|false” custom_margin_tablet=”0px|||” custom_margin_phone=”41px|||-8px|false|false” custom_margin_last_edited=”on|tablet” header_2_font_size_tablet=”32px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/04\/acp_pedigree_02052021.png” title_text=”acp_pedigree_02052021″ align=”center” _builder_version=”4.16.0″ _module_preset=”default” width=”100%” width_tablet=”76%” width_phone=”76%” width_last_edited=”on|phone” min_height=”360px” min_height_tablet=”230px” min_height_phone=”230px” min_height_last_edited=”on|tablet” border_width_all=”6px” border_color_all=”#0C71C3″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ prev_background_color=”#54a885″ admin_label=”Subscribe” _builder_version=”4.16.0″ background_color=”#0439A3″ min_height=”868px” min_height_tablet=”802px” min_height_phone=”903px” min_height_last_edited=”on|phone” height=”868px” height_tablet=”802px” height_phone=”752px” height_last_edited=”on|phone” custom_margin=”-17px||-86px||false|false” custom_margin_tablet=”69px||-148px||false|false” custom_margin_phone=”69px||-148px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”18vw|0|0px||false|false” filter_contrast=”85%” top_divider_style=”wave” top_divider_height=”10vw” top_divider_height_tablet=”12vw” top_divider_height_phone=”15vw” top_divider_height_last_edited=”on|phone” hover_enabled=”0″ box_shadow_style=”preset7″ box_shadow_horizontal=”0px” box_shadow_vertical=”-80px” box_shadow_color=”#ffffff” global_colors_info=”{}” sticky_enabled=”0″][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16.0″ custom_margin=”-191px||||false|false” custom_margin_tablet=”-79px||||false|false” custom_margin_phone=”-123px||||false|false” custom_margin_last_edited=”on|phone” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.0″ text_font=”Arial||||||||” text_font_size=”18px” ul_font=”||||||||” ol_font=”||||||||” header_font=”Archivo||||||||” header_2_font=”Archivo||||||||” header_2_font_size=”32px” header_2_line_height=”1.5em” header_3_font=”||||||||” header_4_font=”||||||||” header_5_font=”||||||||” header_6_font=”||||||||” background_layout=”dark” custom_margin=”-37px||||false|false” custom_margin_tablet=”0px|||” custom_margin_phone=”119px||||false|false” custom_margin_last_edited=”on|tablet” header_2_font_size_tablet=”30px” header_2_font_size_phone=”22px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n
<\/strong><\/p>\n July 19, 2022 – Case Western Reserve University (CWRU) researchers within the Department of Population and Quantitative Health sciences have secured funding through the National Institutes of Health\u2019s (NIH) National Institute on Aging to expand community outreach.\u00a0 This is part of a nationwide effort to better understand a disease that presents differently\u2014and at different rates\u2014in communities that historically have not been included in large-scale genetic research.<\/p>\n \u00a0This enhances research that is foundational to developing prevention strategies, earlier diagnostic tests and treatments for a condition that has no boundaries,<\/em> said Jonathan L. Haines {link to bio}.\u00a0 Read more.\u00a0 {Links to new page}<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/07\/iStock-1290441773-scaled.jpg” title_text=”African American grandmother with her granddaughter” align=”center” disabled_on=”on|on|off” _builder_version=”4.16.0″ _module_preset=”default” custom_margin=”-27px||||false|false” custom_padding=”||13px||false|false” border_width_all=”6px” border_color_all=”#0C71C3″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Subscribe” _builder_version=”4.16.0″ background_color=”#54a885″ min_height=”1000px” height=”1000px” max_height=”1000px” custom_margin=”-10px||0px||false|false” custom_padding=”15vw|0|0px||false|false” filter_contrast=”85%” top_divider_style=”wave” top_divider_color=”#0439A3″ top_divider_height=”10vw” top_divider_height_tablet=”12vw” top_divider_height_phone=”15vw” top_divider_height_last_edited=”on|phone” hover_enabled=”0″ border_color_all=”RGBA(255,255,255,0)” box_shadow_style=”preset7″ box_shadow_horizontal=”0px” box_shadow_vertical=”-80px” box_shadow_color=”#ffffff” global_colors_info=”{}” sticky_enabled=”0″][et_pb_row _builder_version=”4.16.0″ min_height=”412.9px” custom_margin=”-133px|auto||auto|false|false” custom_margin_tablet=”0px||||false|false” custom_margin_phone=”0px||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.0″ text_font=”Arial||||||||” text_font_size=”17px” ul_font=”||||||||” ol_font=”||||||||” header_font=”Archivo||||||||” header_2_font=”Archivo|700|||||||” header_2_font_size=”36px” header_2_line_height=”1.4em” header_3_font=”||||||||” header_4_font=”||||||||” header_5_font=”||||||||” header_6_font=”||||||||” background_layout=”dark” custom_margin=”19px||||false|false” custom_margin_tablet=”0px|||” custom_margin_phone=”-263px||||false|false” custom_margin_last_edited=”on|tablet” hover_enabled=”0″ header_2_font_size_tablet=”” header_2_font_size_phone=”22px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}” text_font_size_last_edited=”on|tablet” sticky_enabled=”0″ text_font_size_tablet=”15px” text_font_size_phone=”15px”]<\/p>\n Most genetic research for AD has focused on non-Hispanic whites of European ancestry. This lack of diversity is problematic, given the higher prevalence of AD among people with African and Hispanic ancestry compared to non-Hispanic whites.<\/p>\n Recent studies published by Dr. Haines and colleagues have shown novel and nuanced findings about genetic variation linked to the\u00a0risk<\/u>\u00a0for AD as well as\u00a0protection from<\/u> AD among people with African and\/or Hispanic ancestry.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16.0″ custom_margin=”-237px|auto||auto|false|false” custom_padding=”5px||||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.0″ text_font=”Arial||||||||” text_font_size=”18px” ul_font=”||||||||” ol_font=”||||||||” header_font=”Archivo||||||||” header_2_font=”Archivo|700|||||||” header_2_font_size=”36px” header_2_line_height=”1.6em” header_3_font=”Archivo||||||||” header_3_font_size=”20px” header_3_line_height=”1.3em” header_4_font=”||||||||” header_5_font=”||||||||” header_6_font=”||||||||” background_layout=”dark” custom_margin=”48px||||false|false” custom_margin_tablet=”0px|||” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” header_2_font_size_tablet=”” header_2_font_size_phone=”20px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n A 2016 study found that a deletion in the\u00a0ABCA7<\/em>\u00a0gene (located on chromosome 19) is an ethnic-specific alteration that\u00a0increases risk<\/u> of AD in individuals with African ancestry (Cukier, Neurology: Genetics<\/em>, 2016).<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16.0″ text_font=”Arial||||||||” text_font_size=”18px” ul_font=”||||||||” ol_font=”||||||||” header_font=”Archivo||||||||” header_2_font=”Archivo|700|||||||” header_2_font_size=”36px” header_2_line_height=”1.6em” header_3_font=”Archivo||||||||” header_3_font_size=”20px” header_3_line_height=”1.3em” header_4_font=”||||||||” header_5_font=”||||||||” header_6_font=”||||||||” background_layout=”dark” custom_margin=”19px||||false|false” custom_margin_tablet=”0px|||” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” header_2_font_size_tablet=”” header_2_font_size_phone=”20px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n A 2018 study showed that Alzheimer\u2019s risk conferred by the APOE-4 varies by the ancestral origin of the genomic region surrounding the APOE gene (Rajabli, PLOS Genetics, 2018), with APOE-4 on the gene conveying African ancestry carrying a far lower Alzheimer\u2019s risk than the APOE-4 on the gene conveying European ancestry. In other words, among people with African American heritage \u2013 who also have European heritage \u2013 variation of the APOE-4 located on the gene conveying European ancestry, conveys a higher risk for Alzheimer\u2019s.<\/p>\n <\/span><\/span><\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16.0″ text_font=”Arial||||||||” text_font_size=”18px” ul_font=”||||||||” ol_font=”||||||||” header_font=”Archivo||||||||” header_2_font=”Archivo|700|||||||” header_2_font_size=”36px” header_2_line_height=”1.6em” header_3_font=”Archivo||||||||” header_3_font_size=”20px” header_3_line_height=”1.3em” header_4_font=”||||||||” header_5_font=”||||||||” header_6_font=”||||||||” background_layout=”dark” custom_margin=”-28px||||false|false” custom_margin_tablet=”0px|||” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” header_2_font_size_tablet=”” header_2_font_size_phone=”20px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n A 2019 study (Kunkle,\u00a0Nature Genetics<\/em>, 2019) continued the nuanced look at genetic architecture and demonstrated associations between genetic variants implicated in AD and cardiovascular conditions, in non-Hispanic whites and among African Americans, pointing to related disease mechanisms of these conditions.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Contact” _builder_version=”4.16.0″ background_color=”#54A885″ background_enable_color=”off” background_image=”http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/04\/map-jpg-1024×512-1.jpg” parallax=”on” min_height=”1000px” min_height_phone=”1000px” min_height_last_edited=”on|phone” height=”1000px” height_phone=”1000px” height_last_edited=”on|phone” max_height_phone=”1000px” max_height_last_edited=”on|phone” custom_margin=”-95px||-472px||false|false” custom_margin_tablet=”-87px||||false|false” custom_margin_phone=”-59px||-1px||false|false” 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box_shadow_color=”rgba(0,0,0,0.2)” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.0″ text_font=”Arial|700||on|||||” text_letter_spacing=”2px” ul_font=”||||||||” background_color=”#0439A3″ text_orientation=”center” background_layout=”dark” width=”98%” custom_margin=”-85px||||false|false” custom_padding=”60px|40px|60px|40px” custom_padding_last_edited=”off|desktop” animation_style=”flip” animation_delay=”200ms” text_font_size_tablet=”” text_font_size_phone=”10px” text_font_size_last_edited=”on|phone” border_width_all=”8px” border_color_all=”#FFFFFF” border_width_top=”8px” border_color_left=”#FFFFFF” locked=”off” global_colors_info=”{}”]<\/p>\n 2103 Cornell Road<\/p>\n Cleveland, Ohio 44106<\/p>\n Audrey.Lynn@case.edu<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”http:\/\/eaglep.case.edu\/haineslab_web\/wp-content\/uploads\/2022\/04\/Capture-logo-only.jpg” title_text=”Capture logo only” align=”center” _builder_version=”4.16.0″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” min_height=”542px” min_height_tablet=”485px” min_height_phone=”345px” min_height_last_edited=”on|desktop” height=”525px” height_tablet=”485px” height_phone=”322px” height_last_edited=”on|phone” custom_margin=”-85px||-32px||false|false” custom_margin_tablet=”8px||-56px|8px|false|false” custom_margin_phone=”5px||-60px|5px|false|false” custom_margin_last_edited=”on|desktop” custom_padding=”||35px||false|false” filter_saturate=”86%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" News & Recent PublicationsCase Western Reserve University to Expand Alzheimer\u2019s Disease Research with Cleveland\u2019s African American Communities July 19, 2022 – Case Western Reserve University (CWRU) researchers within the Department of Population and Quantitative Health sciences have secured funding through the National Institutes of Health\u2019s (NIH) National Institute on Aging to expand community outreach.\u00a0 This […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-771","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=\/wp\/v2\/pages\/771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=771"}],"version-history":[{"count":114,"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=\/wp\/v2\/pages\/771\/revisions"}],"predecessor-version":[{"id":1979,"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=\/wp\/v2\/pages\/771\/revisions\/1979"}],"wp:attachment":[{"href":"http:\/\/eaglep.case.edu\/haineslab_web\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Recent publications focused on people with African and\/or Hispanic Ancestry<\/h2>\n
ABCA7 frameshift deletion associated with Alzheimer disease in African Americans\u00a0<\/strong><\/em><\/a><\/span><\/h3>\n
Ancestral Origin of ApoE e4 Alzheimer disease risk in Puerto Rican and African American Populations<\/strong><\/em><\/a><\/h3>\n
Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates AB, tau, immunity and lipid processing<\/em><\/strong><\/a><\/span><\/h3>\n