{"id":978,"date":"2020-05-27T21:32:05","date_gmt":"2020-05-27T21:32:05","guid":{"rendered":"http:\/\/eaglep.case.edu\/iamdgc_web\/?page_id=978"},"modified":"2026-03-27T20:48:07","modified_gmt":"2026-03-27T20:48:07","slug":"datasets-and-resources","status":"publish","type":"page","link":"http:\/\/eaglep.case.edu\/iamdgc_web\/?page_id=978","title":{"rendered":"Datasets and Resources"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.0.6″ background_color=”#00777f” custom_margin=”||-87px|||” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.0.6″ background_color=”#006787″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_divider _builder_version=”4.0.6″ background_color=”#006787″ global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.0.6″ background_color=”rgba(0,0,0,0)” min_height=”126px” height=”206px” max_height=”211px” custom_margin=”3px||-140px||false|false” custom_padding=”6px||6px||false|false” global_colors_info=”{}”][et_pb_fullwidth_header title=”Your Title Goes Here” button_one_text=” ” _builder_version=”4.0.6″ background_color=”#FFFFFF” custom_button_one=”on” button_one_text_color=”rgba(0,0,0,0)” min_height=”249px” custom_margin=”-87px||-126px|||” custom_padding=”9px||0px|||” global_colors_info=”{}”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.0.6″ background_color=”#006787″ custom_margin=”||-87px|||” custom_padding=”0px|||0px|false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.0.6″ background_color=”#ffffff” custom_margin=”28px|auto|-76px|auto|false|false” custom_margin_tablet=”|-1px||76px|false|false” custom_margin_phone=”5px||-55px|58px|false|false” custom_margin_last_edited=”on|desktop” custom_padding=”||0px||false|false” global_module=”1013″ saved_tabs=”all” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_image _builder_version=”4.0.6″ custom_margin=”-43px|||||” custom_padding=”|||0px|false|false” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”http:\/\/eaglep.case.edu\/iamdgc_web\/wp-content\/uploads\/2020\/05\/AMD-logo-V6_no-fill_small_no_rim.png” _builder_version=”4.0.6″ custom_margin=”-18px||27px|63px|false|false” custom_margin_tablet=”|0px||157px|false|false” custom_margin_phone=”|||40px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”51px||19px|7px|false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_text _builder_version=”4.0.6″ text_font=”Archivo|700|||||||” custom_margin=”|16px||-45px|false|false” custom_margin_tablet=”|||37px|false|false” custom_margin_phone=”-15px||18px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px|12px|34px||false|false” border_color_all=”#0006787″ global_colors_info=”{}”]<\/p>\n

Defining the genomic architecture of Age-related Macular Degeneration (AMD)\u00a0<\/span><\/strong>to improve diagnosis, treatment, and prevention.<\/span><\/strong><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_divider _builder_version=”4.0.6″ background_enable_color=”off” background_image=”http:\/\/eaglep.case.edu\/iamdgc_web\/wp-content\/uploads\/2021\/10\/Try-this-one-scaled.jpg” min_height=”148px” custom_margin=”31px||-133px||false|false” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” global_module=”834″ saved_tabs=”all” global_colors_info=”{}”][\/et_pb_divider][et_pb_image _builder_version=”4.0.6″ background_color=”#FFFFFF” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.0.6″ background_color=”#FFFFFF” custom_margin=”16px||||false|false” custom_padding=”0px||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.0.6″ custom_padding=”||8px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ text_font=”Arial||||||||” text_line_height=”1.8em” background_color=”#FFFFFF” custom_margin=”|0px|||false|false” custom_margin_tablet=”|0px|||false|false” custom_margin_phone=”41px||-17px|0px|false|false” custom_margin_last_edited=”on|desktop” custom_padding=”48px|0px|0px|0px|false|false” custom_padding_tablet=”||0px||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” text_font_size_tablet=”” text_font_size_phone=”2px” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

The members of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC) have jointly assembled the largest collection of AMD case and control DNA in the world.<\/span><\/h3>\n

Our work includes the evaluation of genomic data from the collective ~50,000 sample dataset genotyped on the Illumina HumanCoreExome chip, with additional GWAS and custom content from various other sources, including consortium members’ research libraries.\u00a0The consortium has grown to include nearly 100,000 participants.<\/span><\/h3>\n

<\/h2>\n

<\/h1>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.0.6″ background_color=”#ffffff” background_image=”http:\/\/eaglep.case.edu\/iamdgc_web\/wp-content\/uploads\/2021\/10\/Try-this-one-scaled.jpg” custom_margin=”||||false|false” custom_padding=”0px||0px|0px|false|false” custom_padding_tablet=”” custom_padding_phone=”” custom_padding_last_edited=”on|desktop” global_colors_info=”{}”][\/et_pb_divider][et_pb_image _builder_version=”4.0.6″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.0.6″ custom_padding=”||8px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ text_font=”Arial||||||||” custom_margin=”-55px|||||” global_colors_info=”{}”]<\/p>\n

<\/h3>\n

Our work bridges the gap between association studies of common variants and sequencing studies of rare variants by simultaneously assessing both rare and common variation. The approximately 500,000 markers included on the consortium’s array, along with the more than 11 million subsequently imputed variants, provide superior coverage of known disease susceptibility loci through intentional fine-mapping and improve the power for novel disease locus detection, as this is the largest genomic analysis of AMD to date.<\/span><\/h3>\n

These data support the consortium\u2019s analysis of the genetic architecture of AMD, including more detailed analyses of genes, interactions, pathways, and phenotypes.<\/span><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.0.6″ min_height=”290px” custom_margin=”-9px||-257px||false|false” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”0px||0px|||” global_colors_info=”{}”][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|desktop” _builder_version=”4.0.6″ background_color=”#006787″ height=”306px” max_height=”352px” custom_margin=”-48px||-22px||false|false” custom_margin_tablet=”-20px||-14px||false|false” custom_margin_phone=”||3px||false|false” custom_margin_last_edited=”on|tablet” custom_padding=”0px||0px||false|false” custom_padding_tablet=”” custom_padding_phone=”” global_colors_info=”{}”][et_pb_row _builder_version=”4.14.2″ min_height=”1000px” custom_margin=”|auto|25px|auto|false|false” custom_padding=”37px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_text _builder_version=”4.14.2″ text_font=”Archivo||||||||” text_letter_spacing=”2px” text_line_height=”2.2em” background_color=”#007777f” background_enable_image=”off” height=”216px” max_height=”203px” custom_margin=”21px||32px||false|false” custom_margin_tablet=”||-2px||false|false” custom_margin_phone=”||9px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||false|false” hover_enabled=”0″ border_color_all=”#0C71C3″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

The consortium\u2019s data and summary statistics are available through the\u00a0NHGRI-EBI GWAS Catalog here<\/span><\/em><\/a>.\u00a0 These data are made available through EMBL-EBI’s standard terms of use.\u00a0 \u00a0<\/span> <\/span><\/h3>\n

<\/span><\/h3>\n

<\/span><\/h3>\n

The consortium’s GWAS summary statistics from the 2016 study published in Nature Genetics are available here<\/span><\/em><\/a>.\u00a0<\/span><\/h3>\n

<\/span><\/h3>\n

<\/span><\/h3>\n

Data from research investigating the modulation of genetic effects onlate AMD by age and sex, from the paper published in PLOS ONE in 2018, can be downloaded\u00a0here.<\/span><\/em><\/a><\/span><\/h3>\n

<\/span><\/h3>\n

<\/strong><\/span><\/h3>\n

<\/strong><\/span><\/p>\n

The IAMDGC summary stats from Gorski*, Grunin*, et al IOVS 2025<\/span><\/em><\/a> for the EUR population can be found here<\/span><\/em><\/a>, including betas and p-values. <\/span><\/em><\/a><\/span><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|desktop” _builder_version=”4.0.6″ background_color=”#006787″ height=”306px” max_height=”352px” custom_margin=”-48px||-22px||false|false” custom_margin_tablet=”-20px||-14px||false|false” custom_margin_phone=”||3px||false|false” custom_margin_last_edited=”on|tablet” custom_padding=”0px||0px||false|false” custom_padding_tablet=”” custom_padding_phone=”” global_colors_info=”{}”][et_pb_row _builder_version=”4.14.2″ min_height=”100px” custom_margin=”|auto|25px|auto|false|false” custom_padding=”37px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.0.6″ background_color=”#FFFFFF” custom_margin=”-44px||-24px|||” custom_padding=”37px|||||” global_colors_info=”{}”][et_pb_row custom_padding_last_edited=”on|desktop” _builder_version=”4.0.6″ custom_padding_tablet=”4px||6px||false|false” custom_padding_phone=”0px||2px||false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_text _builder_version=”4.0.6″ text_font=”Archivo||||||||” global_colors_info=”{}”]<\/p>\n

\u00a0If you are interested in working with us and using our datasets, please contact us.<\/span><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.0.6″ background_color=”#006787″ custom_margin=”||||false|false” custom_padding=”39px|||||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.0.6″ background_color=”#FFFFFF” custom_margin=”||||false|false” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|phone” custom_padding=”|||0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_image src=”http:\/\/eaglep.case.edu\/iamdgc_web\/wp-content\/uploads\/2020\/05\/AMD-logo-V6_no-fill_small_no_rim.png” _builder_version=”4.0.6″ custom_margin=”||||false|false” custom_margin_tablet=”|||89px|false|false” custom_margin_phone=”” custom_margin_last_edited=”on|phone” custom_padding=”|80px||72px|false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.0.6″ global_colors_info=”{}”][et_pb_text _builder_version=”4.0.6″ text_font=”Archivo||||||||” custom_margin=”||||false|false” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”|||9px|false|false” global_colors_info=”{}”]<\/p>\n

Contact us:<\/span><\/h1>\n

Susan Halloran Blanton, PhD<\/span><\/h3>\n

Project Manager, IAMDGC<\/span><\/h3>\n

Email:\u00a0 SBlanton@med.miami.edu<\/span><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Defining the genomic architecture of Age-related Macular Degeneration (AMD)\u00a0to improve diagnosis, treatment, and prevention.The members of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC) have jointly assembled the largest collection of AMD case and control DNA in the world. Our work includes the evaluation of genomic data from the collective ~50,000 sample dataset genotyped on […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":""},"_links":{"self":[{"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=\/wp\/v2\/pages\/978"}],"collection":[{"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=978"}],"version-history":[{"count":59,"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=\/wp\/v2\/pages\/978\/revisions"}],"predecessor-version":[{"id":1757,"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=\/wp\/v2\/pages\/978\/revisions\/1757"}],"wp:attachment":[{"href":"http:\/\/eaglep.case.edu\/iamdgc_web\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}