Our Research


Alzheimer’s Disease


Age-related Macular Degeneration

Alzheimer’s Disease (AD)

The Haines Lab focuses on the genetic architecture of Alzheimer’s Disease (AD),  drawing on vast data sets as well as unique and/or historically underserved communities.

Research within Amish communities has provided foundational insights more readily attainable because of the nature of these populations.  {embed link}

The Lab’s engagement with communities historically underrepresented in genetics research is based on a long-standing commitment to ensuring that all benefit from the foundational work that informs precision medicine for diagnosis, prevention, and treatment.

The scale of data required for comprehensive genetics research requires collaboration through large consortia, many of them co-founded and directed by Dr. Haines.   {consortia page might be phase II)


Macular Degeneration (AMD)

This is the most common cause of severe vision loss among the elderly.

AMD is known for variable progression of the disease, although there are no well-defined biomarkers that track this progression.

Since genetic variation strongly influences the risk of developing AMD, the Haines Lab hypothesizes that genetic variation also influences disease progression.

This focus on progression complements the Lab’s ongoing work on the genetic architecture of risk and protection.

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Cleveland, Ohio 44106