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Defining the genomic architecture of Age-related Macular Degeneration (AMD) to improve diagnosis, treatment, and prevention.

The consortium includes 33 academic and independent research institutes. 


The International AMD Genomics Consortium (IAMDGC) was formed in 2012 to aggregate genetic and genomic data from research groups across the world, with the goal of illuminating the genetic architecture of AMD.

The IAMDGC built upon the success of the AMD gene consortium, which started in 2010 under the leadership of Drs. Margaret Pericak-Vance and Jonathan Haines with the support of Dr. Hemin Chin, then the Director, Ocular Genetics and Center Core Grant Programs, Division of Extramural Research, National Eye Institute.

The IAMDGC has greatly expanded the number of participating groups, the amount of genetic data, and the analytical methods of analyzing these data. It published the largest AMD GWAS to date, and the data from that GWAS have been used in subsequent publications to identify new loci.


Our work centers on

  • Expanding IAMDGC resources and datasets with a focus on family data and diverse genetic ancestry

  • Expanding the range of clinical diagnostic measures

  • Using an analytical hub infrastructure to perform detailed analyses of our collective and individual members’ data

Meet our Principal Investigators 

Jonathan L. Haines, PhD

The Cleveland Institute for Computational Biology at Case Western Reserve University School of Medicine

Margaret (Peggy) Pericak-Vance, PhD

John P. Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine

Contact us:

Susan Halloran Blanton, PhD

Project Manager, IAMDGC