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Defining the genomic architecture of Age-related Macular Degeneration (AMD) to improve diagnosis, treatment, and prevention.

 

Our consortium members regularly publish in peer-reviewed journals.

Featured publications are listed below and a full listing of research done with IAMDGC datasets follows.  

Landmark papers:  

Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci

Recent papers:  

Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration

A Transcriptome-Wide Association Study Based on 27 Tissues Identifies 106 Genes Potentially Relevant for Disease Pathology in Age-Related Macular Degeneration

List of Publications and Presentations from the IAMDGC:

1.  Rare and low-frequency coding variants alter human adult height. Marouli E, et al. 2017 Feb 9;542(7640):186-190. doi: 10.1038/nature21039. Epub 2017 Feb 1. PMID: 28146470 PMCID: PMC5302847

2. A Scalable Bayesian Method for Integrating Functional Information in Genome-wide Association Studies. Yang J, Fritsche LG, Zhou X, Abecasis G; International Age-Related Macular Degeneration Genomics Consortium. Am J Hum Genet. 2017 Sep 7;101(3):404-416. doi: 10.1016/j.ajhg.2017.08.002. Epub 2017 Aug 24. PMID: 28844487

 3. Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores. Ding Y, Liu Y, Yan Q, Fritsche LG, Cook RJ, Clemons T, Ratnapriya R, Klein ML, Abecasis GR, Swaroop A, Chew EY, Weeks DE, Chen W; AREDS2 Research Group. Genetics. 2017 May;206(1):119-133. doi: 10.1534/genetics.116.196998. Epub 2017 Mar 24. PMID: 28341650

 4. Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1. Persad PJ, Heid IM, Weeks DE, Baird PN, de Jong EK, Haines JL, Pericak-Vance MA, Scott WK; for the International Age-Related Macular Degeneration Genomics Consortium (IAMDGC). Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4027-4038. PMID: 28813576 PMCID: PMC5559178

5. Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Grassmann F, Kiel C, Zimmermann ME, Gorski M, Grassmann V, Stark K; International AMD Genomics Consortium (IAMDGC), Heid IM, Weber BH. Genome Med. 2017 Mar 27;9(1):29. doi: 10.1186/s13073-017-0418-0. PMID: 28347358 PMCID: PMC5368911

6. Improved score statistics for meta-analysis in single-variant and gene-level association studies. Yang J, Chen S, Abecasis G; IAMDGC. Genet Epidemiol. 2018 Jun;42(4):333-343. doi: 10.1002/gepi.22123. Epub 2018 Apr 25. PMID: 29696691

7. Investigating the Modulation of Genetic Effects on Late AMD by Age and Sex: Lessons Learned and Two Additional Loci. Winkler, T. W., Brandl, C., Grassmann, F., Gorski, M., Stark, K., Loss, J., Weber, B. H. F. Heid, I. M. PLoS One. 2018;13(3):e0194321. Published 2018 Mar 12. doi:10.1371/journal.pone.0194321 PMID: 29529059

8. Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration. Lorés-Motta L, Paun CC, Corominas J, et al. Ophthalmology. 2018;125(7):1064–1074. PMID: 29398083

9. Association of Genetic Variants With Response to Anti-Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration. Lorés-Motta L, Riaz M, Grunin M, Corominas J, van Asten F, Pauper M, Leenders M, Richardson AJ, Muether P, Cree AJ, Griffiths HL, Pham C, Belanger MC, Meester-Smoor MA, Ali M, Heid IM, Fritsche LG, Chakravarthy U, Gale R, McKibbin M, Inglehearn CF, Schlingemann RO, Omar A, Chen J, Koenekoop RK, Fauser S, Guymer RH, Hoyng CB, de Jong EK, Lotery AJ, Mitchell P, den Hollander AI, Baird PN, Chowers I. JAMA Ophthalmol. 2018 Aug 1;136(8):875-884. doi: 10.1001/jamaophthalmol.2018.2019. PMID: 2985203.

10. Y chromosome mosaicism is associated with age-related macular degeneration. Grassmann F, Kiel C, den Hollander AI, Weeks DE, Lotery A, Cipriani V, Weber BHF; International Age-related Macular Degeneration Genomics Consortium (IAMDGC). Eur J Hum Genet. 2019 Jan;27(1):36-41. doi: 10.1038/s41431-018-0238-8. Epub 2018 Aug 29. PMID: 30158665

11. Geographic distribution of rare variants associated with age-related macular degeneration. Geerlings MJ, Kersten E, Groenewoud JMM, Fritsche LG, Hoyng CB, de Jong EK, den Hollander AI. Mol Vis. 2018 Jan 27;24:75-82. eCollection 2018. PMID: 29410599

12. Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration. Waksmunski AR, Grunin M, Kinzy TG, Igo RP Jr, Haines JL, Cooke Bailey JN; International Age-Related Macular Degeneration Genomics Consortium. Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):4041-4051. doi: 10.1167/iovs.19-27827. PMID: 31560769

13. On the differences between mega- and meta-imputation and analysis exemplified on the genetics of age-related macular degeneration. Gorski M, Günther F, Winkler TW, Weber BHF, Heid IM. Genet Epidemiol. 2019;43(5):559–576. doi:10.1002/gepi.22204 PMID: 31016765

14. Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470. Louer EMM, Lorés-Motta L, Ion AM, Den Hollander AI, Deen PMT. RNA Biol. 2019 Nov;16(11):1547-1554. doi: 10.1080/15476286.2019.1643100. Epub 2019 Jul 24. PMID: 31304868 Free PMC article.

15. A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration. Strunz T, Lauwen S, Kiel C; International AMD Genomics Consortium (IAMDGC), Hollander AD, Weber BHF. Sci Rep. 2020;10(1):1584. Published 2020 Jan 31. doi:10.1038/s41598-020-58510-9 PMID: 32005911

16. Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration. Valentina Cipriani, Laura Lorés-Motta, Fan He, Dina Fathalla, Viranga Tilakaratna, Selina McHarg, Nadhim Bayatti, İlhan E. Acar, Carel B. Hoyng, Sascha Fauser, Anthony T. Moore, John R. W. Yates, Eiko K. de Jong, B. Paul Morgan, Anneke I. den Hollander, Paul N. Bishop & Simon J. Clark 2020 Nature Comm Feb 7;11(1):778. doi: 10.1038/s41467-020-14499-3. PMID: 32034129

17. Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data. Grassmann F; International AMD Genomics Consortium (IAMDGC), Weber BHF, Veitia RA. Hum Genet. 2020; 139(3):401–407. doi:10.1007/s00439-019-02029-1 PMID: 31134332

18. Association of a Variant in VWA3A with Response to Anti-Vascular Endothelial Growth Factor Treatment in Neovascular AMD. Grunin M, Beykin G, Rahmani E, et al. Invest Ophthalmol Vis Sci. 2020;61(2):48. doi:10.1167/iovs.61.2.48 PMID: 32106291

19. Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration. Han X, Ong JS, An J, Hewitt AW, Gharahkhani P, MacGregor S. [published online ahead of print, 2020 Jan 3]. Eur J Epidemiol. 2020;10.1007/s10654-019-00598-z. doi:10.1007/s10654-019-00598-z PMID: 31900758

20. Family-based exome sequencing identifies rare coding variants in age-related macular degeneration. Ratnapriya R, Acar İE, Geerlings MJ, Branham K, Kwong A, Saksens NTM, Pauper M, Corominas J, Kwicklis M, Zipprer D, Starostik MR, Othman M, Yashar B, Abecasis GR, Chew EY, Ferrington DA, Hoyng CB, Swaroop A, Hollander AI. Hum Mol Genet. 2020 Apr 3:ddaa057. doi: 10.1093/hmg/ddaa057. Online ahead of print. PMID: 32246154

21. Pleiotropic Locus 15q24.1 reveals a gender-specific association with neovascular but not atrophic age-related macular degeneration. Kiel C, Strunz T, International AMD Genomics Consortium (Project Manager Blanton S), Grassmann F, Weber BHF. Cells. 2020 Oct 8. 9:2257 doi:10.3390/cells9102257.

Submitted:

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease. TW Winkler et al. bioRxiv 2019.12.20.883801 tel://20191220883801; doi: https://doi.org/10.1101/2019.12.20.883801 Submitted to BMC Medical Genomics

Publications in which the IAMDGC is acknowledged:

  1. Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD). Grassmann F, Cantsilieris S, Schulz-Kuhnt AS, White SJ, Richardson AJ, Hewitt AW, Vote BJ, Schmied D, Guymer RH, Weber BH, Baird PN. J Neuroinflammation. 2016 Apr 18;13(1):81. doi: 10.1186/s12974-016-0548-0. PMID: 27090374 PMCID: PMC4835888
  2. The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review. Cooke Bailey JN, Hoffman JD, Sardell RJ, Scott WK, Pericak-Vance MA, Haines JL. J Clin Med. 2016 Mar 4;5(3). pii: E31. doi: 10.3390/jcm5030031. Review. PMID: 26959068 PMCID: PMC4810102
  3. The impact of the human genome project on complex disease Genes (Basel). Bailey JN, Pericak-Vance MA, Haines JL. 2014 Jul 16;5(3):518-35. doi: 10.3390/genes5030518. PMID: 25032678 PMCID: PMC4198915
  4. Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol-Associated Mechanisms in Etiology of Age-Related Macular Degeneration. Burgess S, Davey Smith G. Ophthalmology. 2017 Aug;124(8):1165-1174. doi: 10.1016/j.ophtha.2017.03.042. Epub 2017 Apr 26. PMID: 28456421 PMCID: PMC5526457
  5. HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization. Fan Q, Maranville JC, Fritsche L, Sim X, Cheung CMG, Chen LJ, Gorski M, Yamashiro K, Ahn J, Laude A, Dorajoo R, Lim TH, Teo YY, Blaustein RO, Yoshimura N, Park KH, Pang CP, Tai ES, Khor CC, Wong TY, Runz H, Cheng CY. Int J Epidemiol. 2017 Sep 12. PMID: 29025108
  6. Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization. Zuber V, Colijn JM, Klaver C, Burgess S. Nat Commun. 2020;11(1):29. Published 2020 Jan 7. doi:10.1038/s41467-019-13870-3
  7. Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration. Han X, Ong JS, An J, Hewitt AW, Gharahkhani P, MacGregor S. Eur J Epidemiol. 2020 Jan 3. doi: 10.1007/s10654-019-00598-z. Online ahead of print. PMID: 31900758

Contact us:

Susan Halloran Blanton, PhD

Project Manager, IAMDGC

Email:  SBlanton@med.miami.edu